One Health Trust uses research and stakeholder engagement to improve the health and well-being of our planet and its inhabitants. OHT builds on the work of the Center for Disease Dynamics, Economics & Policy (CDDEP), which for more than a decade conducted vitally important research on major global health challenges, including COVID-19, antimicrobial resistance, hospital infections, tuberculosis, malaria, pandemic preparedness and response, vaccination, medical oxygen shortages, and noncommunicable diseases. OHTs work now expands to take on issues related to climate change, biodiversity protection, and the effect of human diets on the planet.